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7-Ethyl-10-hydroxycamptothecin CAS NO.86639-52-3
- Min.Order: 100 Metric Ton
- Payment Terms: L/C,T/T,MoneyGram,Other
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- 86639-52-3
- Sell high quality 7-Ethyl-10-hydroxycamptothecin
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- ProName: 7-Ethyl-10-hydroxycamptothecin
- CasNo: 86639-52-3
- Molecular Formula: C22H20N2O5
- Appearance: light-yellow solid
- Application: Used for research and industrial manuf...
- DeliveryTime: Within7-10 days after receipt of your...
- PackAge: As customer request
- Port: Qingdao,China
- ProductionCapacity: 100kg/Month Metric Ton/Day
- Purity: 98%min
- Storage: Store in a cool,dry place and keep awa...
- Transportation: Common products:Sea/Air/Courier Dange...
- LimitNum: 100 Metric Ton
Superiority
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.
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| 7-Ethyl-10-hydroxycamptothecin Basic information |
| Product Name: | 7-Ethyl-10-hydroxycamptothecin |
| Synonyms: | CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-ETHYL-10-HYDROXYCAMPTOTHECINE;7-ETHYL-10-HYDROXY-CPT;SN38;10-dihydroxy-;4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3 |
| CAS: | 86639-52-3 |
| MF: | C22H20N2O5 |
| MW: | 392.4 |
| EINECS: | |
| Product Categories: | Pharmaceutical Raw Materials;Miscellaneous Natural Products;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors |
| Mol File: | 86639-52-3.mol |
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| 7-Ethyl-10-hydroxycamptothecin Chemical Properties |
| mp | 217 °C |
| refractive index | 21.5 ° (C=0.2, THF) |
| storage temp. | −20°C |
| CAS DataBase Reference | 86639-52-3(CAS DataBase Reference) |
| 7-Ethyl-10-hydroxycamptothecin Usage And Synthesis |
| Chemical Properties | Light-Yellow Solid |
| Usage | A metabolite of Irinotecan, a DNA topoisomerase inhibitor |
| Biological Activity | Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). |
| 7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials |
| Preparation Products |
Irinotecan |
