China (Mainland)
Premiumsupplier
R-406 CAS NO.841290-80-0
- Min.Order: 0 Metric Ton
- Payment Terms: L/C,T/T,MoneyGram,Other
- Product Details
Keywords
- R-406
- Tamatinib
- R406
Quick Details
- ProName: R-406
- CasNo: 841290-80-0
- Molecular Formula: C22H23FN6O5
- Appearance: Off-white to white solid powder
- Application: Intermediate used for preparation of p...
- DeliveryTime: Within 3-7 days after receipt of your ...
- PackAge: As customer request
- Port: Qingdao\Shanghai,China
- ProductionCapacity: 100 Kilogram/Week
- Purity: 99%
- Storage: Store in a cool,dry place and keep awa...
- Transportation: By Sea/Air/Courier
- LimitNum: 0 Metric Ton
- Appearance: N/A
Superiority
Details
R-406(841290-80-0)
[PRODUCTNAME]:6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
[CATALOG NUMBER]:
[CAS NUMBER]:841290-80-0
[MOLECULAR FORMULA]:C22H23FN6O5
[MOLECULAR WEIGHT]:470.45400
[BATCH NO]: 20190218
[TEST]:SPECIFICATION
[APPEARANCE]: White Solid
[ASSAY]: 98%min
[WATER]: 0.5%max
R-406 Usage And Synthesis
| Uses | Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents. |
| Uses | R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical] |
