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AZD2281(olaparib) CAS NO.763113-22-0
- Min.Order: 1 Gram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- Olaparib
- AZD2281(olaparib)
- 99%Olaparib
Quick Details
- ProName: AZD2281(olaparib)
- CasNo: 763113-22-0
- Molecular Formula: C24H23FN4O3
- Appearance: White Solid
- Application: Olaparib is a potent poly(ADP-ribose) ...
- DeliveryTime: Within7-10 days after receipt of your ...
- PackAge: As customer request
- Port: Qingdao,China
- ProductionCapacity: 100 Kilogram/Week
- Purity: 99%
- Transportation: By Sea/Air/Courier
- LimitNum: 1 Gram
Superiority
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.
Details
Olaparib
| CAS: | 763113-22-0 |
| MF: | C24H23FN4O3 |
| MW: | 434.469 |
| Appearance: | White solid |
| Assay: | 99% |
| desnity: | 1.43 |
| Uses: Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death. | |
