N-Hydroxysuccinimide CAS NO.6066-82-6

N-Hydroxysuccinimide

Product Name:N-Hydroxysuccinimide

Synonyms:N-HYDROXY-2,5-PYRROLIDINEDIONE;NHS;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE

CAS:6066-82-6

MF:C4H5NO3

Melting point:95-98 °C(lit.)

Purity/Quality:98%

Appearance/Colour:Clear yellow-brown to brown Liquid or Solid

Chemical properties:Soluble inDMSO (Slightly), Methanol (Slightly) .Has Hygroscopic.Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.

Uses:N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.

Packaging:5kg aluminum foil bag, 25kg cardboard drum packaging

Storage temp:2-8°C