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cabozantinib (S)-malate CAS NO.1140909-48-3
- Min.Order: 100 Metric Ton
- Payment Terms: L/C,T/T,MoneyGram,Other
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- 1140909-48-3
- Sell high quality cabozantinib (S)-malate produced in China factory
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Quick Details
- ProName: cabozantinib (S)-malate
- CasNo: 1140909-48-3
- Molecular Formula: C28H24FN3O5.C4H6O5
- Appearance: white powder
- Application: Used for research and industrial manuf...
- DeliveryTime: Within7-10 days after receipt of your ...
- PackAge: As customer request
- Port: Qingdao,China
- ProductionCapacity: 100kg/Month Metric Ton/Day
- Purity: 98%min
- Storage: Store in a cool,dry place and keep awa...
- Transportation: Common products:Sea/Air/Courier Dange...
- LimitNum: 100 Metric Ton
Superiority
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.
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| Cabozantinib Malate Basic information |
| Product Name: | Cabozantinib Malate |
| Synonyms: | (2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1);Cabozantinib (S)-malate;Cabozantinib L-Malate Salt;N-[4-[(6,7-DiMethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide (2S)-;Cabozantinib (S)-Malate(XL-184);Cabozantinib L-Malate;Cabozantinib Malate (XL184);XL-184 (Malate) |
| CAS: | 1140909-48-3 |
| MF: | C32H30FN3O10 |
| MW: | 635.5931032 |
| EINECS: | |
| Product Categories: | Inhibitors |
| Mol File: | 1140909-48-3.mol |
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| Cabozantinib Malate Chemical Properties |
| Safety Information |
| Cabozantinib Malate Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Usage | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell a poptosis. |
| Usage | XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. |
| Usage | Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respective |
